By; Mathew D. Morton NMD A summary of ozone's history and a brief overview of the various protocols of of medical ozone.
INTRODUCTION
Ozone, a highly active form of oxygen, possesses unique properties which are being defined and applied to biological systems as well as to clinical practice. As a molecule containing a large excess of energy, Ozone manifests bactericidal, virucidal and fungicidal actions which makes it a treatment in other conditions.
Ozone, best known for its protective role in the earth's ecological harmony, and for its interaction at ground level with industrial pollutants, has unique biological properties which have been investigated for applications in various medical fields.
As early as the first World War, Ozone's bactericidal properties were used to treat infected wounds, mustard gas burns and fistulas.
There first treatment attempts, however, were hampered by technological difficulties. Medical Ozone generators have since been developed and refined. They differ from industrial generators in their capacity to deliver the purest Ozone-Oxygen mixtures in needed amounts.
A critical advance in medical ozone technology was the development, in the early 60's of plastics which could adequately carry this mixture and permit proper administration to patients. In the last few years Ozone treatment has seen growing interest from diverse therapeutic groups.
BIOCHEMICAL PROPERTIES
The oxygen atom exists in nature in several forms:
1) As a free atomic particle (0), it is highly reactive and unstable.
2) Oxygen (02), its most common and stable form, is colorless as a gas
3) Ozone (03) has a density one and a half times that of oxygen.
Ozone is a powerful oxidant. Of importance to biological systems is Ozone's interaction with tissue, especially blood.
These dynamics are especially relevant for medical applications because some of the most practiced methods in Ozone therapy involve the mixing of a small volume of whole blood with a pure ozone/oxygen mixture and subsequently returning it to the patient.
In this manner, it is calculated that the dose of Ozone administered will perform its therapeutic functions without disrupting blood composition.
The production of Ozone-Oxygen mixtures for human and veterinary applications is subject to important technical consideration. Clinical Ozone generators which regulate the flow of medical grade oxygen through high voltage tubes with outputs ranging from 4000V to 14,000V are capable of producing Ozone-Oxygen mixtures within concentration ranges extending to five percent, predicated by three variables:
1) the voltage applied
2) the oxygen flow rate
3) the electrode separation distance
Nitrogen, in the presence of high energy fields, forms nitric oxides. (27) It is the nitric oxide which at one time was considered toxic, but in actuality plays an important role in bringing about the health of the immune system and the maintenance of optimum health.
Since the half life of Ozone is 45 minutes at 68 degrees Fahrenheit, in two hours losing its concentration to 16% of its initial value, it must be freshly generated for immediate use at the treatment site. The maximum dose generated is 5% Ozone to 95% oxygen.
Caution is needed not to mix ether and ozone, an especially reactive mixture. Also, no Ozone should be taken if the following conditions are present: acute alcohol intoxication, recent heart attacks, hemorrhage in any organ, pregnancy, hyperthyroidism, blood clots and Ozone allergy.
METHODS OF ADMINISTRATION, DOSAGE AND CLINICAL APPLICATIONS EXTERNAL OZONE GAS APPLICATION
Ozone was first administered by application to external body surfaces. A.Wolff, in 1915, is credited for using local Ozone treatments for wounds, fistulas, decubitus ulcers and osteomyelitis.
Today, specially designed plastic, enables the body to be comfortably encased in a space where a determined ratio of Oxygen to Ozone is administered at a chosen flow rate.
Indication for external Ozone application include poorly healing wounds, burns, staphylococcal infections, fungal and radiation lesions, herpes simplex and zoster, and gangrene diabetic or non-diabetic). Dosage is adjusted to the condition treated. High Ozone concentrations are used for disinfection and cleaning, while low concentrations promote healing.
OZONE INSUFFLATION
Payr in 1935 (3) and Augourg in 1936 (6) first used Ozone-Oxygen mixtures in rectal insufflation. The list of indications has expanded to include many conditions.
It is reported that in inflammatory diseases of the bowel, Ozone promotes healing and restores the floral balance distrubed by harmful germs.
In a typical treatment, daily insufflations are applied starting with 50 ml and increasing as tolerated in increments until 500 ml are administered. (7) This technique is of use in the treatment of bowel infections associated with AIDS. Microsporidia, a tiny, rarely detected parasite may be responsible for many cases of AIDS wasting illness, (8) and studies of this germ's susceptibility to Ozone treatment has been reported.
MAJOR AUTOHEMOTHERAPY (AHT)
Whereas it can be readily understood that external Ozone applications produce local effects such as disinfection, wound healing or local circulatory enhancement, the technique of introducing Ozone in the circulation as in the technique of major autohemotherapy, 50 to 100 ml of blood is drawn from the patient, mixed with adose of Ozone-Oxygen, then returned via the same intravenous catheter to the patient, where the Ozonated blood is rapidly distributed to all tissues.
With blood infusions, Ozone exerts therapeutic actions locally; virucidal activity, Oxygenation, increased red cell fluidity and promotes increased beneficial systemic activity. (9) Of interest, are the report of some patients, who after receiving this treatment experience feelings of well-being lasting for a few minutes to several hours.
MISCELLANEOUS APPLICATIONS
Although the above techniques of ozone administration represent the majority of hospital or office based procedures, others deserve mention.
MINOR AUTOHEMOTHERAPY
In this technique, 10 ml of venous blood is drawn from the patient, mixed with Ozone-Oxygen, then injected intramuscularly. Listed indications include asthma, acne, some allergic conditions and some cases of arthritis.
OZONE IN WATER
Ozone is approximately ten times more soluble in water than oxygen. Mixed into water, the half life of Ozone is nine to ten hours at pH7 and 68 degrees Fahrenheit. It may be rinsed orally in conditions such as thrush and periodontal disease, swallowed in cases of gastritis or stomach cancer, or irrigated in chronic bladder inflammation.
OZONE OINTMENTS
Ozonated olive oil provides long term, low dose exposure of Ozone to tissues, and it may be used topically or consumed by drinking small amounts of used on salads.
HYDROTHERAPY
Ozonated water bubbled in warm baths provides stimulation of local circulation and a disinfectant action to varicosities, circulatory disorders and dermatological conditions (eczema, ulcers, psoriasis, etc.)
METABOLIC AND PHYSIOLOGICAL EFFECTS OF OZONE
Pulmonary effects of Ozone in low doses include metabolic activation of lung cells; but with Ozone, one must avoid the escape of Ozone into the treatment area.
For the reason that below 0.30 ppm the probability of Ozone traversing the respiratory epithelium and entering the systemic circulation is so low, very few studies have attempted to measure these effects. (12) The techniqe of major autohemotherapy and others that involve the direct introduction of Ozone in the circulation, shows that Ozone exposure increases metabolic activity of red blood cells.
According to other researchers, the direct intravascular injection of pure Ozone/Oxygen mixtures results in the following response; an activation of enzymes involved in oxygen radical scavenging, releasing oxygen to the tissues.
BACTERICIDAL, VIRUCIDAL AND FUNGICIDAL ACTION
Although the inhibition and lethal effects of Ozone on disease producing organisms have been observed since the latter part of the nineteen century, these actions have not yet been completely explained. Ozone is a strong germicide needing only a few micrograms per liter for measurable action.
Viruses differ in their susceptibility to destruction by Ozone.
The most cited explanation for Ozone's bactericidal effects centers on disruption of envelope integrity. There is evidence for interaction with proteins as well.
In one study exploring the effect of Ozone on E. coli, evidence was found for Ozone's penetration of the cell membrane. In clinical treatment with Ozone, Ozone appears to be toxic to infecting organisms and not to the patient.
Ozone possesses fungicidal effects. In one study, Candida cell growth inhibition with Ozone was greatly dependent on phases of their growth, budding cells exhibiting the most sensitivity to its presence.
Viruses are parasites at the genetic level. Lipid-containing viruses are sensitive to treatment with Ozone. Viruses containing lipid coatings include the Herpes viruses, a large family grouping the Simplex, Zoster, Cytomegalovirus and Epsteinn-Barr viruses, mumps, measles, influenza, rabies and the HIV virus.
In those clinical applications which make use of external or body cavity application of Ozone, inactivation of microorganisms, bacteria, viruses or fungi, proceeds by a variety of different methods. The treatment of burns, superficial infections, ulcers and abscesses is approached by this method, which is the absorption of Ozone through the skin and the mucous membranes.
Since very little free Ozone remains in the solution due to its high reactivity, its products interact with circulation as well as tissue-bound viruses, thus inactivating them.
Although unproven to be an outright curative for any viral illness, Ozone blood treatment, as reported in several studies should lessen clinical severity or duration. Thus, therapeutic benefits have been noted in hepatitis, acute and chronic, and herpes.
In chronic viral infections-Cytomegalic, Epstein-Barr and Retrovirus (AIDS) among others, blood Ozonation administered during viral cycles or in periods of clinical detection may, through the production of co-factors be inhibitory to viral replication, modify immune function, and be a tool in inducing viral suppression.
Ozone is reported to be an immunostimulant in low doses.
OZONE TREATMENT IN CANCER
The logic sustaining the use of Ozone/Oxygen application to the treatment of cancers rests on the strategy of taking advantage of the disturbed metabolism of cancer cells.
Since the first biochemical hypothesis of cancer was proposed by Warburg: All tumors have higher rates of destruction with Oxygen than do non-tumor cells. It was for this that Warburg won the Nobel Prize in 1931.
Some authors report a peroxide intolerance in tumor cells. The authors postulate that cancer cells are less able to compensate for the oxidative challenge of Ozone than normal cells. T
here are many clinical and anecdotal reports of Ozone usually major or minor autohemotherapy, at times prescribed on a daily basis for several weeks, applied to the treatment of various cancer conditions. Several researchers have focused their efforts on using ozone as an adjunct to radiation or chemotherapy. Proving a greater degree of treatment success.
VIRAL INACTIVATION BY OZONE
The inactivation of viral particles by Ozone takes place by a variety of methods. Viruses, unlike cells, lack enzymes designed to repair injured DNA or RNA and are destroyed by this process.
IMMUNOLOGICAL PATHWAYS
In recent years it has been discovered that nitric oxide, a gas under atmospheric conditions traditionally associated with toxicity, actually exerts essential biological functions.
It has a free radical structure, is short lived and is an eager electron contributor. Aside from its activity as a neurotransmitter and as an antihypertensive agent, nitric oxide appears to be an essential component of the mechanisms by which macrophages become activated to destroy tumor cells, bacteria and viruses.
Macrophages, scavengers of the immune system, become activated to creating minuscule amounts of nitric oxide using arginine, and the enzyme nitric oxide synthase. Without nitric oxide, macrophages remain idle. It has also been shown that nitric oxide is directly toxic to tumor cells.
It is in this context - through the skin's absorption of Ozone/Oxygen that remarkable results have been shown. The use of a cabinet of airtight suit enclosure, while using Ozone/Oxygen generated with Oxygen or air has demonstrated a high percentage of absorption through the two square yards of skin.
This passage of Ozone/Oxygen through the skin takes place when the skin is wet.
Ozone, with the mobilization of its own free radical structure begins the activation of nitric oxide macrophages thus promoting their purifying mission.
Ozone's interaction with biological systems and its activities in harmful germ inactivation are varied, and complex. The recent discoveries that nitric oxide and carbon monoxide assume crucial functions in regulating metabolic and physiological health, should give new research drive to the therapeutic properties of Ozone.
It has been clearly shown that: (1) Ozone/Oxygen combined with, (2) proper nutrition, (3) exercise and (4) a positive mental attitude, can bring about superior results in the maintenance of optimum health when supervised by a well trained physician.
In 1953, 40 years ago, the research of Dr. Harry Goldblatt was published in the Journal of Experimental Medicine. His research confirmed that the lack of oxygen plays a major role in causing cells to become cancerous.
Dr. Albert Wall also determined that "disease is due to a deficiency in the oxidation (burning) process of the body, leading to an accumulation of toxins. These toxins are burned in normal metabolic functioning."
Dr. Wendell Hendricks of the Hendricks Research Foundation wrote "Cancer is a condition within the body where oxidation has become so depleted that the body cells have degenerated beyond physiological control."
The important part of what Dr. Hendricks said is that you can "remove the cause of tumors by oxidizing the body toxins." Oxidizing body toxins can only be done with sufficient oxygen.
But how do you get sufficient oxygen into the blood stream so it can be carried to each and every one of the trillion body cells? It can be accomplished with supercharged Oxygen, namely, Ozone.
SUMMARY
In closing, Ozone application for infections, burns, dental, intestinal conditions, and circulatory disorders is the most effective and safe way of treating these problems. As for blood Ozonation, research has proven its effectiveness in improving:
1) Immunological, endocrine, neurological, metabolic and hormonal systems.
2) The inhibition and destruction of cancers.
3) The inactivation and/or destruction of viral, bacterial, fungal, and yeast infections.
4) OZONE IS OUR MOST POTENT HEALTH PROTECTOR
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